
Our Mass Spectrometry core offers:
- A Complete Service - sample receipt and storage, sample preparation, instrument analysis, data interpretation and reporting.
- Analytical Research - Training in Chromatography and MS technology. Assay Development for novel methods
- Open Access - Independent use of instrumentation following Training or prior knowledge
Celebrating the widespread use of Mass Spectrometry
Edinburgh Mass Spectrometry core laboratory video tour
The secret life of a core facilities manager
For more videos and information on Mass Spectrometry world wide go to the Masses for the Masses website.
Masses for the Masses - Interactive Map
CMVM Core Facilities Fair Publication Policy
Instrumentation and Equipment within the Mass Spectrometry Core
- Sciex QTrap 5500 LC-MS/MS (Sciex) with SelexION (differential ion mobility) with ESI, APCI and APPI sources and interfaced to an Acquity UPLC-MS/MS (Waters). Metabolite identification software
- ThermoFisher Quantum Ultra GC-MS/MS (ThermoFisher) with split/splitless, PTV and headspace injectors, direct insertion probe and EI, PCI and NCI sources
- Voyager GC-MS with EI and NCI sources
- Waters Xevo TQS tandem mass spectrometer with Waters I-Class UPLC
- Waters Synapt G2Si with DESI and MALDI capability and M-class (microflow)
- Solid Phase Extraction vacuum manifolds
- High-throughput sample preparation systems including 96-well evaporator and 96-well vacuum manifold
- Nitrogen Generated for high purity sample concentration
Established quantitative Mass Spectrometry assays we offer in clinical samples
- Simultaneous assays for endogenous Steroids in plasma and serum
- Glucocorticoids and mineralocorticoids (cortisol, cortisone, corticosterone, 11-dehydrocorticosterone, deoxycortisol, deoxycorticosterone, aldosterone)
- Androgens (testosterone, dihydrotestosterone, dehydroepiandrosterone, androstenedione)
- Estrogens (estradiol, estrone, estriol and 2 and 4-hydroxyestrogens, 2 and 4-methoxyestrogens)
- Urinary Steroid profiles: Glucocorticoid and Androgen Metabolites
- Synthetic Steroids: Mifepristone (RU38486), dexamethasone, 11-dehydrodexamethasone, 6-hydroxy-dexamethasone, alfaxolone, Canrenone, Spironolactone
- Diuretics: Hydrochlorothiazide (HCTZ) ,trichlormethiazide (TCZ)
- Anti-diabetic agents: metformin, glyburide, gliclazide
- Statins (e.g. Simvastatin)
- Paracetamol and Phase I and Phase II metabolites (Acetaminophen), Phenacetin, Paracetamol phase I and II metabolites (mercapturate-acetaminophen, glutathione-acetaminophen, acetaminophen-sulphate, 3-cysteinyl-acetaminophen, acetaminophen-glucuronide)
- Tryptophan and Kynurenine metabolites (3-Hydroxy Kynurenine, 3-hydroxyanthranilic Acid, Anthranilic Acid, Xanthurenic Acid, Kynurenic Acid, Quinolinic Acid, Tryptophan, 5-hydroxytryptophan)
- Vitamin D (VitDAL)
- Endocannabinoids: Anandamide, 2-arachidonylglycerol (2-AG)
- Prostatic therapies: 5-alpha reductase inhibitors (finasteride, dutasteride), tamsulosin
- Pharmacology: e.g. Rocuronium, Lidocaine, Isoflurane
- Stable isotope tracers of metabolism: isotopically labelled fatty acids (13C-palmitate), D2-glucose, D5-glycerol, D4-cortisol, D8-corticosterone
- Microsomal Stability assays - including lidocaine, propranolol, verapamil and diclofenac
Assay Development
We are able to adapt existing published methods or develop novel analytical quantitative methods. Analysis can be conducted in a wide range of biomatrices supporting both clinical and preclinical studies.